Columbia University Medical Center
Center for Radiological research

NIH Program Project on
Radiation Bystander Effects: Mechanism
PO1-CA 49062-17

Recent Publications that are supported either fully or partially by the Program Project:

  1. Bertucci A, Pocock RD, Randers-Pehrson G and Brenner DJ. Microbeam irradiation of the C. elegans nematode. J Radiat Res. 50:A49-54, 2009. [abstract]
  2. Bigelow A, Garty G, Funayama T, Randers-Pehrson G, Brenner D and Geard C. Expanding the question-answering potential of single-cell microbeams at RARAF, USA. J Radiat Res. 50 Suppl A: A21-8, 2009. [abstract]
  3. Chai Y and Hei TK. Radiation induced bystander effect in vivo. Acta Med Nagasaki. 53: 65-69, 2009.
  4. Hei TK, Ballas LK, Brenner DJ and Geard CR. Advances in radiobiological studies using a microbeam. J. Radiat Res. 50 Suppl A: A7-A12, 2009. [abstract]
  5. Hei TK, Zhou H, Ivanov VN. The Yin and Yang of low dose radiobiology. In: Nakashima, M., Takamura, N., Tsukasaki, K., Nagayama, Y., and Yamashita, S. (eds). Radiation Health Risk Sciences. Springer, Tokyo, 2009, pp.135-142.
  6. Hu B, Shen B, Su Y, Geard CR and Balajee AS. Protein kinase C epsilon is involved in ionizing radiation induced bystander response in human cells. Int J Biochem Cell Biol. 2009 Jul 3. [Epub ahead of print] [abstract]
  7. Ivanov VN, Zhou H, Partridge MA and Hei TK. Inhibition of Ataxia Telangiectasia Mutated Kinase activity enchances TRAIL-Mediated apoptosis in human melanoma cells. Cancer Research. 69: 3510-3519, 2009. [abstract]
  8. Shuryak I and Brenner DJ. A model of interactions between radiation-induced oxidative stress, protein and DNA damage in Deinococcus radiodurans. J Theor Biol. 2009 Aug 11. [Epub ahead of print]. [abstract]
  9. Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK and Brenner DJ. A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approach. Radiat Environ Biophys. 48: 263-74, 2009. [abstract]
  10. Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK and Brenner DJ. A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation. Radiat Environ Biophys. 48:275-86, 2009. [abstract]
  11. Su Y, Meador JA, Geard CR and Balajee AS. Analysis of ionizing radiation-induced DNA damage and repair in three-dimensional human skin model system. Exp Dermatol. 2009 Jul 23. [Epub ahead of print].[abstract]
  12. Zhou H, Hong M, Chai Y and Hei TK. Consequence of cytoplasmic irradiation: studies from microbeam. J Radiat Res. 50 Suppl A: A59-A65, 2009. [abstract]
  13. Zhou H, Suzuki M, Hong M, Ivanov V, Partridge M, Randers-Pehrson G and Hei TK. Mitochondrial function modulates cytoplasmic irradiation induced bystander effect. J Radiat Res. 50: A103, 2009.
  14. Amundson SA. Functional genomics in radiation biology: a gateway to cellular systems-level studies. Radiat Environ Biophys. 47: 25-31, 2008. [abstract]
  15. Amundson SA. Functional genomics and a new era in radiation biology and oncology. Bioscience 58: 491-500, 2008.
  16. Baskar R, Balajee AS, Geard CR and Hande MP. Isoform-specific activation of protein kinase c in irradiated human fibroblasts and their bystander cells. Int J Biochem Cell Biol. 40:125-134, 2008. [abstract]
  17. Bigelow AW, Brenner DJ, Garty G and Randers-Pehrson G. Single-particle/single-cell ion microbeams as probes of biological mechanisms. IEEE Trans. Plasma Sci. 36:1424-1431, 2008.
  18. Bigelow AW, Geard CR, Randers-Pehrson G and Brenner DJ. Microbeam-integrated multiphoton imaging system. Rev Sci Instrum. 79:123707, 2008. [abstract]
  19. Chen SP, Zhao Y, Han W, Zhao GP, Zhu J, Wang J, Bao L, Jiang E, Xu A, Hei TK, Yu ZL and Wu LJ. Mitochondria dependent signaling pathways are involved in early process of radiation induced bystander effects. Brit J Cancer. 98: 1839-1844, 2008. [abstract]
  20. Ghandhi SA, Yaghoubian B and Amundson SA. Global gene expression analyses of bystander and alpha particle irradiated normal human lung fibroblasts: synchronous and differential responses. BMC Med Genomics. 1: 63, 2008. [abstract]
  21. Hei TK, Zhou H, Ivanov VN, Hong M, Lieberman HB, Brenner DJ, Amundson SA and Geard CR. Mechanism of radiation induced bystander effects: a unifying model. J Pharmacy and Pharmacology 60: 943-950, 2008 [Top 25 papers of the year award]. [abstract]
  22. Ivanov VN, Partridge MA, Johnson GE, Huang S, Zhou HN and Hei TK. Resveratrol sensitizes melanomas to TRAIL through modulation of anti-apoptotic gene expression. Exp. Cell Research 314:1163-76, 2008. [abstract]
  23. Paul S and Amundson SA. Development of gene expression signatures for practical radiation biodosimetry. Int J Radiat Oncol Biol Phys. 71(4): 1236-1244, 2008. [abstract]
  24. Zhou H, Ivanov V, Lien YC, Davidson M and Hei TK. Mitochondrial Function and NF-κB Mediated Signaling in Radiation-Induced Bystander Effects. Cancer Research 68:2233-40, 2008. [abstract]
  25. Baskar R, Balajee AS and Geard CR. Effects of low and high LET radiations on bystander human lung fibroblast cell survival. Int J Radiat. Biol. 83(8):551-9, 2007. [abstract]
  26. Han W, Wu L, Chen S, Bao L, Zhang K, Jiang EW, Zhao Y, Xu A, Hei TK and Yu Z. Constitutive nitric oxide acting as a possible intercellular signaling molecule in the initiation of radiation-induced DNA double strand breaks in non-irradiated bystander cells. Oncogene 26: 2330-9, 2007.
  27. Hei TK. Radiation-Induced Bystander Effects: Mechanisms and Implication for Low-Dose Radiation Risk Assessment. Radiat Res. 167: 347-348, 2007.
  28. Hei TK, Zhou HZ, Lien YC and Zhao YL. Mechanism of radiation carcinogenesis: BigH3, COX-2 and beyond. Int. Congress Series, 1299: 114-20, 2007.
  29. Li H, Gu Y, Miki J, Hukku B, McLeod DG, Hei TK and Rhim JS. Malignant transformation of human benign prostate epithelial cells by high linear energy transfer alpha-particles. Int J Oncol. 31(3):537-44, 2007.[abstract]
  30. Ivanov VN, Zhou H and Hei TK. Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells. Cancer Research 67: 5397-5407, 2007. [abstract]
  31. Partridge MA, Davidson MM and Hei TK. The complete nucleotide sequence of Chinese hamster mitochondrial DNA. DNA Sequence 18: 341-6, 2007. [abstract]
  32. Persaud R, Zhou H, Hei TK and Hall EJ. Demonstration of a radiation induced bystander effect for low dose low LET beta-particles. Radiat. Environ. Biophys. 46:395-400, 2007. [abstract]
  33. Ponnaiya B, Jenkins-Baker G, Randers-Pehrson G and Geard CR. Quantifying a bystander response following microbeam irradiation using single-cell RT-PCR analyses. Experimental Hematology. 35:64-8, 2007. [abstract]
  34. Sedelnikova OA, Nakamura A, Kovalchuk O, Koturbash I, Mitchell SA, Marino SA, Brenner DJ and Bonner WM. DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models. Cancer Res. 67:4295-4302 2007. [abstract]
  35. Shuryak I., Sachs R.K. and Brenner D.J. Biophysical models of radiation bystander effects: 1. Spatial effects in three-dimensional tissues. Radiat. Res. 168:741-749, 2007. [abstract]
  36. Bigelow AW, Ross GJ, Randers-Pehrson G and Brenner DJ. Multiphoton microscope design for the Columbia University Microbeam II endstation. Radiation Research 166:664, 2006.
  37. Calaf GM, Roy D and Hei TK. Growth factor biomarkers associated with estrogen- and radiation-induced breast cancer progression. Int. J. Oncology 28: 87-93, 2006.
  38. Garty G, Ross GJ, Bigelow AW, Randers-Pehrson G and Brenner DJ. Testing the stand-alone microbeam at Columbia University. Radiat Prot Dosimetry. 122:292-6, 2006.
  39. Garty G, Ross GJ, Bigelow AW, Schettino G, Randers-Pehrson G and Brenner DJ. Status of the Stand-Alone Microbeam at Columbia University. Radiation Research 166:656, 2006.
  40. Hei TK. Cyclooxygenase-2 as a signaling molecule in radiation induced bystander effect. Mol. Carcinogenesis 45: 455-60, 2006. [abstract]
  41. Hu B, Wu L, Han W, Zhang L, Chen S, Xu A, Hei TK and Yu Z. The time and spatial effects of bystander response in mammalian cells induced by low dose radiation. Carcinogenesis 27:245-251, 2006. [abstract]
  42. Ross GJ, Ponnaiya B, Bigelow AW, Randers-Pehrson G and Brenner DJ. Update on incorporating no-stain imaging into microbeam endstation. Radiation Research 166:667-8, 2006.
  43. Roy D, Calaf GM, Hande M and Hei TK. Allelic imbalance at 11q23-q24 chromosome associated with estrogen and radiation-induced breast cancer progression. Int. J. Oncology 28: 667-74, 2006.
  44. Schettino G, Randers-Pehrson G and Brenner DJ. Development of a soft X-ray microbeam at RARAF. Radiation Research 166:661-2, 2006.
  45. Shuryak I., Sachs R.K., Hlatky L., Little M.P., Hahnfeldt P. and Brenner D.J. Radiation-induced leukemia at doses relevant to radiation therapy: Modeling mechanisms and estimating risks. J Natl Cancer Inst. 98:1974-1806. 2006. [abstract]
  46. Zhou H, Xu A, Gillispie JA, Waldren CA and Hei TK. Quantification of CD59(-) mutants in human-hamster hybrid (A(L)) cells by flow cytometry. Mutat Res 594: 113-9, 2006. [abstract]
  47. Zhou H, Suzuki M, Gillispie J, Randers-Pehrson G and Hei TK, Cytoplasmic radiation induced bystander mutagenesis. Radiation Research 166:689, 2006.
  48. Belyakov OV, Mitchell SA, Parikh D, Randers-Pehrson G, Marino SA, Amundson SA, Geard CR and Brenner DJ. Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away. PNAS (USA), 102(40): 14203-8, 2005.[abstract]
  49. Bigelow AW, Randers-Pehrson G, Kelly RP and Brenner DJ. Laser Ion Source for Columbia University's Microbeam. Nucl. Instr. and Meth. in Phys. Res. B 241: 874-879, 2005.
  50. Bigelow AW, Ross GJ, Randers-Pehrson G and Brenner DJ. The Columbia University Microbeam II endstation for cell imaging and irradiation. Nucl. Instr. and Meth. in Phys. Res. B 231: 202-206, 2005.
  51. Calaf GM, Roy D and Hei TK. Immunochemical analysis of protein expression in breast epithelial cells transformed by estrogens and high linear energy transfer (LET) radiation. Histochem Cell Biol 124: 261-274, 2005. [abstract]
  52. Garty G, Randers-Pehrson G & Brenner DJ. Development of a secondary-electron ion-microscope for microbeam diagnostics. Nuclear Instruments and Methods in Physics Research Section B 231: 60-64, 2005.
  53. Garty G, Ross GJ, Bigelow A, Randers-Pehrson G and Brenner DJ. A microbeam irradiator without an accelerator. Nuclear Instruments and Methods in Physics Research Section B 241: 392-396, 2005.
  54. Hall EJ, Brenner DJ, Worgul B and Smilenov L. Genetic susceptibility to radiation. Adv. Space Res. 35:249-253, 2005. [abstract]
  55. Hei TK, Zhou H and Suzuki M. Extranuclear target and low dose radiation risk assessment. Int. Congress Series 1276: 21-24, 2005.
  56. Hu B, Han W, Wu L, Feng H, Liu X, Zhang L, Xu A, Hei TK and Yu Z. In situ visualization of DSBs to assess the extranuclear/extracellular effects induced by low-dose alpha-particle irradiation. Radiat Res 164:286-291, 2005. [abstract]
  57. Persaud R, Zhou H, Baker SE, Hei TK and Hall EJ. Assessment of low LET radiation induced bystander mutagenesis in a three dimensional culture. Cancer Research 65: 9876-9882, 2005. [abstract]
  58. Piao CQ, Liu L, Zhao YL, Balajee AS, Suzuki M and Hei TK. Immortalization of human small airway epithelial cells by ectopic expression of telomerase. Carcinogenesis 26: 725–731, 2005. [abstract]
  59. Ravi P, Zhou H, Baker SE, Hei TK and Hall EJ. Assessment of low LET radiation induced bystander mutagenesis in a three dimensional culture. Cancer Research 65: 9876-82, 2005.
  60. Ross GJ, Bigelow AW, Randers-Pehrson G, Peng CC, Brenner DJ. Phase-based cell imaging techniques for microbeam irradiations. Nucl. Instr. & Meth in Phys. Res. B 241: 387-391, 2005.
  61. Ross GJ, Garty G, Randers-Pehrson G, Brenner DJ. A single-particle/single-cell microbeam based on an isotopic alpha source. Nuclear Instruments and Methods in Physics Research Section B 231: 207-211, 2005.
  62. Ross GJ, Ponnaiya B, Bigelow AW, Randers-Pehrson G and Brenner DJ. Update on incorporating no-stain imaging into microbeam endstation. Radiat Res. 166: 667-8, 2006.
  63. Zhou H, Ivanov VN, Gillespie J, Geard CR, Amundson SA, Brenner DJ, Yu Z , Lieberman HB and Hei TK. Mechanism of radiation-induced bystander effect: Role of the cyclooxygenase-2 signaling pathway. PNAS (USA), 102(41): 14641-6, 2005. [abstract]
  64. Zhou H, Suzuki M, Persaud R, Gillispie J, Randers-Pehrson G and Hei TK. Contribution on bystander effects in radiation induced genotoxicity. Acta Med Nagasaki. 50: 73-77, 2005.
  65. Zhu A, Zhou H, Marino SA, Leloup C, Geard CR, Hei TK and Lieberman HB. Differential impact of mouse rad9 deletion on ionizing radiation-induced bystander effects. Rad Res 164:655-61, 2005. [abstract]

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